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This finding sheds light on the lactate clinical utility to treat aging-related disorders as a response-activating agent [178]

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This is due to an impairment in dTMP synthesis which leads to cell cycle arrest in S-phase of rapidly proliferating cells, in particular hematopoietic cells

Renal Function and Dialysis Research Kidney disease profoundly affects L-Carnitine homeostasis, creating a research area at the intersection of renal physiology and metabolism: Renal Carnitine Handling: Investigation of tubular reabsorption via OCTN2, urinary excretion patterns, and renal threshold determinations

The clinical relevance of these changes was further supported by the reduction in mean OFF time, which correlated with a reduction in ON time with troublesome dyskinesia