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Click here for a more detailed explanation and illustration of how the FRT functions in a firearm

The amount of nicotine released from the nicotine pouches over sixty minutes (60 min) in artificial saliva and its rate of release, used to generate a nicotine dissolution release profile for each nicotine pouch product, was studied following FDA guidance for industry using a USP-4 flow-through cell apparatus (SOTAX, Westborough, MA) and twelve (12) replicates for each nicotine pouch product 14

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