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Anupama N, Preetha Rani MR, Shyni GL, Raghu KG

HNF4 regulates the transcription of SAA metabolic enzymes To further understand how HNF4 regulates SAA metabolism and the resulting cellular sensitivity to methionine/cystine restriction and sorafenib, we tested whether SAA metabolic enzymes are direct transcription targets of HNF4 since the expression of HNF4 is strongly correlated with those of SAA metabolic genes in liver cancer (Fig

e , Schematic showing how the iron-sulfur cluster-containing protein LIAS enables OGDH and PDH activity by transferring lipoic acid as a cofactor to their enzyme complexes (left)

But you should have reasonable expectations, and you should always get medical advice before using supplements