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These uric acid crystals activate pattern recognition receptors (PRRs), including Toll-like receptors (TLRs), NOD-like receptors, and the NLRP3 inflammasome

Golub, Jessica L

In addition, cigarette smoke has known immunomodulatory properties throughout the body 7 , including increasing alveolar macrophage numbers in the airway and elevating neutrophil recruitment to the lung 8

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The competition included events such as the fastest smoker to finish one, five or 10 cigarettes