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Moreover, our results revealed that the TGF-1-induced upregulation of total ATF6 protein levels and the subsequent nuclear translocation and activation of ATF6, as well as the increased expression of CHOP and GRP78, were inhibited by HOXA2 overexpression plasmids

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Glutathione is generally recognized as safe at supplemental doses (up to 1000 mg daily), though long-term safety studies are limited

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However, for the same concentration range, a constant exposure can yield a harmful depletion of GSH to 30% of normal after 14 hours, indicated by the black-dashed line (Fig

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