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10.26402/jpp.2018.3.11 5 Belosic HalleZ.VlainicJ.DrmicD.StrinicD.LueticK.SucicM.et al (2017)

Compounds that demonstrate clear efficacy in rat tendon healing studies have repeatedly failed to reproduce those effects in human clinical trials this is a documented pattern across pharmaceutical development, not a theoretical concern

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Products are labeled for Research Use Only (RUO) in accordance with applicable FDA guidance and 21 CFR 809.10(c)(2) and are not drugs, dietary supplements, or medical products

The 28-day rule is not based on visual inspection but on the cumulative risk of contamination and the guaranteed efficacy of the benzyl alcohol preservative