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These insights have led to therapeutic strategies targeting hypoxia and tumor metabolism, including HIF-2 inhibitors (e.g., belzutifan), hypoxia-activated prodrugs, anti-angiogenic agents, glycolysis and glutaminase inhibitors, lactate transport blockers, CAIX inhibitors, and immunometabolic modulators aimed at reversing hypoxia-induced immune suppression [ Table 1 ]

40 Essential oils of Anethum graveolens and Thymus daenensis exhibited higher lipid peroxidation inhibitory effects than synthetic standard compounds

Their determination could serve as a screening test in monitoring the occurrence of undesirable autoimmune reactions during DPA treatment

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