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Raising the legal age to buy tobacco to 21 is expected to make it more difficult for high school students to access products containing nicotine because 21-year-olds are outside their social networks, according to a report commissioned by the FDA in 2013

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Trials of combination NRT were used to inform this estimate because: (1) randomized trials of a high-dose nicotine patch are not available to inform the projected treatment size, and (2) similar to nicotine patch, combination NRT also allows upward titration to reach satiety