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Gritstone Biotech employed Venezuelan equine encephalitis virus-based self-amplifying mRNA vector in a lipid nanoparticle called GRT-R910 encoding both the prefusion stabilized full-length SARS-CoV-2 spike and additional conserved T-cell epitopes from ORF3a, NP and membrane (Table 3)

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377,378,379 IDH1 mutations in human cancers favor consuming the NADPH for 2-HG synthesis at the expense of other NADPH-requiring pathways essential for cell viability even when NADPH is limiting

It remains an open question why for example cattle and dogs presumably lost their complete set of -defensin genes while in the horse the number increased extensively