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It reduces the invasiveness of endometrial stromal cells and curbs the progression of endometriosis in nude mouse models (153)

By contrast, within a hypoxic TME, tumor-infiltrating NK cells exhibit severe mitochondrial fragmentation, which impairs their tumor-killing capacity and immune surveillance function, thus promoting tumor immune evasion (94)

Thus, we do not expect that our model will make perfect quantitative predictions

Genetic depletion of MAPKAPK2 abolishes these protective effects, whereas re-expression of MAPKAPK2 restores resistance to oxidative stressinduced cellular injury