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Spermidine , a polyamine found in wheat germ and aged cheese that induces autophagy, and magnesium L-threonate , a magnesium form marketed for crossing into the brain, both rest on small or preliminary trials with no clear cognitive benefit yet

Bakker WJ, Harris IS, Mak TW (2007) Foxo3a is activated in response to hypoxic stress and inhibits Hif1-induced apoptosis via regulation of Cited2

However, its long-term use requires balancing potential risks, such as cardiovascular disease and breast cancer