943 NG/EDA is triggered by the acidic and edaravone-induced high levels of GSH microenvironment, enabling selective and sustained release of edaravone at the site of ischemic injury to enhance its neuroprotective effects
Key Insights: Helps lower blood pressure and improve blood circulation Effective in managing hypertension and angina (chest pain) Long-acting drug convenient once-daily dosing Plays a role in reducing the risk of heart attack & stroke Points to Remember: Common side effects include ankle swelling (edema), dizziness, and headache Not suitable for immediate relief of angina Overdose may lead to severe hypotension and complications Why this is important
Health Benefits: Powerful Antioxidant Action L-Glutathione scavenges free radicals helping to prevent oxidative stress that occurs with the build up of free radicals
Grants-in-Aid for Scientific Research on Innovative Areas (to Masayuki Yamamoto and Hozumi Motohashi) from the MEXT
Combinative treatment of -elemene and cetuximab could induce ferroptosis of KRAS-mutant colorectal cancer cells (CRC) by iron-dependent ROS accumulation, GSH depletion, lipid peroxidation, upregulation of HO-1 and transferrin, and downregulation of negative regulatory proteins for ferroptosis (GPX4, SLC7A11, FTH1, glutaminase, and SLC40A1), thus inhibiting tumor growth and lymph node metastases in vivo ( Curcuma zedoaria [Zingiberaceae
