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Therefore, in reference to the ILEP recommendations [2], the authors of these guidelines point to the need of possibly optimum non-pharmacological management (lifestyle modification), and in case of failure (unfortunately, this may apply to up to 80% of individuals) [152], after not more than 6 months, to consider initiation of pharmacological treatment, i.e

However, there is insufficient scientific evidence to confirm the effectiveness of glutathione for all these purposes

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The incidence of breast cancer is increasing each year, and there will be more than 3 million new breast cancer cases annually by 2040 (Nagini, 2017), patients still face the risk of recurrence and mortality, with 685,000 deaths recorded in 2020 (Courtney et al., 2022)

5 Discussion and perspectives In recent years, in OA, a complex degenerative joint disease, increasing research indicates that ferroptosis not only exists in the pathological process but is also closely related to pathological features such as articular cartilage degeneration, synovial inflammation, and subchondral bone changes