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Your goal is to create a solution with a known, easy-to-work-with concentration

Controls simultaneously received an equivolume of saline (5.0 ml/kg ip) or water only (12 ml/rat/day)

NNMT inhibition addresses the deficit by preventing the enzyme (NNMT) that wastes the precursor from inside the cell

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It effectively resolved my concerns regarding bacterial growth during multi-dose applications over several weeks