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Conversely, hypoxia and glucose deprivation in the brain promotes HDAC9 expression in endothelial cells, which has been associated to decreased expression of ZO-1, claudin-5, and occludin (Shi et al., 2016)

Pinzer, T

It's also theoretically possible, though not documented, that the powerful angiogenic effects of BPC-157 could be a concern in subjects with pre-existing conditions where new blood vessel growth is undesirable

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