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41 In detail, the elevated extracellular ATP induced by SD stress stimulates P2 7 R and down-regulates the expression of 5-HT 2B R by suppressing the activation of AKT, which inhibits the phosphorylation of FoxO3a and promotes its transportation into the nucleus, the reduced 5-HT 2B R alleviates the inhibition of STAT3 to cPLA 2 , the activated cPLA 2 further increases the release of AA and PGE2, these indicators have high relationship with the depressive-like behaviors, because in P2X 7 R knockout mice, the above changes of these indicators and behavioral performance are all eliminated
However, increased KIM-1 may also play role in renal tubular epithelial cells regeneration after acute injury (Xie et al
PC-specific transfer protein and non-specific lipid transfer proteins may play a role, but animal studies suggest that neither accounts for the entirety of PC movement (Vance 2014)
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