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When NNMT runs too high in fat tissue, it wastes a form of vitamin B3 that the body needs to make NAD+

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This could be due to racial differences in B12 metabolism, or in environmental factors, most obviously diet (B12 intake)

Complete rest from aggravating activities for at least the first 2 to 4 weeks of treatment allows the enhanced healing response to gain traction before gradually reintroducing load