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The present data demonstrated that the expression of both Bim and PUMA were significantly higher in the tumor samples with GSTP1 GG-genotype than the samples with AA-genotype (p value 0.006 for Bim and 0.01 for PUMA ) (Fig

Inhibition of the p62-KEAP1-NRF2 antioxidant signaling pathway can significantly enhance the anticancer activity of erastin and sorafenib in liver cancer cells in vivo and in vitro [67]

In fact, insulin sensitivity, lipid parameters and HOMA index were greatly improved despite the fact that no changes in lifestyle were requested

It is essential for ensuring liver detoxification, eliminating free radicals, and controlling the skins synthesis of melanin

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