By selectively disrupting key antioxidant systemssuch as inhibiting glutathione synthesis with buthionine sulfoximine (BSO), blocking thioredoxin reductase with auranofin, or directly targeting NRF2therapies can push cancer cells beyond their limited oxidative buffering capacity
BrandhorstSChoiIYWeiMChengCWSedrakyanSNavarreteGet al
Overman MJ, Morris V, Kee B, Fogelman D, Xiao L, Eng C, Dasari A, Shroff R, Mazard T, Shaw K, Vilar E, Raghav K, Shureiqi I, Liang L, Mills GB, Wolff RA, Hamilton S, Meric-Bernstam F, Abbruzzese J, Morris J, Maru D, Kopetz S
One of the strategies currently ongoing is to optimize delivery methods so that the virus moves silently into tumor cells before the host generates an immune response to clear the virus
We can begin to look at you at a much broader level to try and figure out where are you headed and why