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It has also been demonstrated that in spinal cord tissue from sALS patients, loss of nuclear TDP-43 correlates with strand breaks and DDR response, as some in vitro DNA damage cell models revealed that TDP-43 is involved in non-homologous end-joining-mediated repair

It remains to be seen how CMS will handle discussions with states about their existing DSHP and DSIP authority or how states will respond in future Section 1115 waiver proposals and renewals