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These observations suggest the existence of specialized transporters that mediate glutathione flux across the ER membrane

This approach facilitates personalized interventions such as DGAT1 inhibitors for obese patients exhibiting astrocytic lipid droplet accumulation [278], or NAD + boosters for elderly patients with impaired ketone utilization, as exemplified in the SPAN trial [47, 48, 255]

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The supplementary biochemical analysis was applied to the DBA/1J mice ( n = 12