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Once one or more of these protective mechanisms are compromised, bacteria or their products such as endotoxins (lipopolysaccharides, LPS) may breach the intestinal epithelium and disseminate to mesenteric lymph nodes and even distant organs like liver and lungs

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( B ) Under conditions of APAP overdose along with iron overload, the excessive cellular free iron reacts with mitochondrial reactive oxygen species (ROS) to induce lipid peroxidation (LPO) of membranes