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However, in another intervention trial with combination therapy (53), the risk of adverse effects was significantly higher in the Se supplementation group, which we speculate may be related to unclear baseline Se levels in the subjects and a narrower safety window during Se treatment

J Biol Chem 275:93639368 Mulder H, Lu D, Finley J 4th et al (2001) Overexpression of a modified human malonyl-CoA decarboxylase blocks the glucose-induced increase in malonyl-CoA level but has no impact on insulin secretion in INS-1-derived (832/13) beta-cells

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96930), and the ORF of the blasticidin resistance gene (Bsd) was replaced with a puromycin resistance gene (PuroR) by restriction cloning