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Combination therapy has shown somewhat higher rates of GI events compared to either monotherapy, and slow, gradual dose titration significantly improves tolerability

Although a well-planned vegan or vegetarian diet can provide the most essential nutrients, Vitamin B12 is predominantly found in animal-based foods like meat, eggs, and dairy products

This allows tissue recovery and reduces the buildup of irritation

Temperature regulation changes during tirzepatide therapy may coincide with or exacerbate other medication-related side effects

Hypoxia potentiates LPS-mediated cytotoxicity of BV2 microglial cells in vitro by synergistic effects on glial cytokine and nitric oxide system