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No clinical trial has tested this specific combination, but the theoretical basis for synergy is compelling

Mean age-adjusted cognition composite of the NIH Cognition Toolbox Test Battery following administration of l-theanine and l-theaninecaffeine combination were respectively 11.5 and 11.4 points greater than the mean cognition composite score achieved following administration of placebo (p = 0.040, Cohens d = 1.041 and p = 0.041, Cohens d = 1.034 respectively)

doi: 10.1016/j.gene.2021.145992 261 JaiswalSAyyannanSR

Pyridoxine (B6) - Pyridoxine, vitamin B6, is required by your body for utilization of energy in the foods you eat, production of red blood cells, and proper functioning of nerves

The two are complementary and non-redundant: GHK-Cu for dermis and adnexae, BPC-157+TB-500 for deep structures (tendons, ligaments, muscles, gut)