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Among the upregulated genes are those encoding DNA repair enzymes (BRCA1, ATM), extracellular matrix proteins (COL1A1, COL3A1, ELN) and antioxidant enzymes (SOD1, SOD2, GPX)

In a model of amyotrophic lateral sclerosis (ALS) caused by C9orf72 gene mutations, the pathogenic poly-dipeptide GA50 directly binds to and inhibits SQOR, leading to excessive NLRP3 inflammasome activation in microglia and consequent mitochondrial dysfunction ( A growing body of preclinical work supports this strategy: boosting SQOR activity or reducing H 2 S can protect the nervous system

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Nayan Patel, PharmD, Founder of Auro Wellness and CEO of Central Drugs Compounding Pharmacy

The programmability and dynamics allow them to serve as precision building blocks that undergo programmed intracellular assembly and accumulate at the site of interest, thereby improving their specificity and pharmacokinetics 6,20