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doi: 10.1038/s41419-018-0412-5 105 YaoLSgadariCFurukeKBloomETTeruya-FeldsteinJTosatoG

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Mattsson K, Nilsson-Condori E, Elmerstig E, et al

Several considerations should be accounted for, besides accurate mass (AM) and retention time (RT), which includes the elimination of background signals, deisotoping, recognition of adduct peaks in spectra, and MS/MS fragmentation pattern compared to databases or internal standards and the matching degree estimated (Figure 2)