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J Cell Mol Med (2019) 23(8):51939

Silent information regulator 2-related enzyme 1 (SIRT1) is a deacetylase dependent on nicotinamide adenine dinucleotide, which is highly expressed in a variety of tumors and has been proven to inhibit the growth of breast cancer cells ( Estrogen regulates tumor growth by binding to ER66 in the cytoplasm

which indicating that exercise-induced changes in the oxidation capacity are regulated by PGC-1 [88]

7

Various techniques, such as incorporating a cell-penetrating peptide (CPP) sequence or lipid conjugation, were employed to facilitate the intracellular delivery of the peptides 43