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They have long been used as antioxidant enzymes to play an important role in combating oxidative stress and maintaining redox balance

If transient proline metabolites were dangerous, every meal would be toxic

In pioneering work, Anderson et al

Daily administration of cPMP to patients resolved all metabolic abnormalities associated with defective sulfite oxidase and xanthine pathways and prevented further signs of neurologic deterioration (43, 44)

Nutraceuticals and herbal medications are important owing to their low toxicity, availability, and less side effects compared with synthetic drugs 4, 5, 6, 7, 10, 11, 12, 13