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High levels of cannabinoid quinones in commercial vaping products and additional accumulation following vaping is significant as quinones can exert toxicity through multiple mechanisms, primarily modification of proteins or other biological molecules and redox cycling

Bibcode:1994CarEv...9..223P

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Similarly, the RIF dose used in our mice study was not consistent throughout the treatment duration

Elevated expression of AARS1 and lactylation of p53 are often associated with poor prognosis of patients, and administration of -alanine to antagonize the lactylation of p53, coupled with doxorubicin to activate the transcriptional activity of p53, can significantly inhibit the proliferation of tumor cells in animal models [23]