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The mechanism is not entirely clear, but B12 plays a role in nervous system function and neurotransmitter synthesis, which may help modulate the nausea response triggered by GLP-1 receptor activation in the brainstem

doi: 10.3389/fmolb.2022.925700 Received 21 April 2022 Accepted 29 June 2022 Published 22 July 2022 Volume 9 - 2022 Edited by Yan Chen, Second Xiangya Hospital, Central South University, China Reviewed by Jungang Xie, Huazhong University of Science and Technology, China Zhiyi He, Guangxi Medical University, China Updates Copyright 2022 Zhang, Yan, Lu and Zhou

Dose titration planning Standard tirzepatide protocols start at 2.5 mg per week and increase in 2.5 mg increments every four weeks

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