Furthermore, investigations into the combination of CB-839 with immunotherapy have yielded encouraging outcomes, exemplified by its synergistic effect with nivolumab in patients diagnosed with melanoma, clear cell renal cell carcinoma, and NSCLC [217]
Funding This study was supported by the Medical Science Research Program of Hebei Province (20220709), the Government Funded Clinical Medicine Excellent Talent Training Project (ZF2022034), and the Hebei Natural Science Foundation (H2022316005)
Glucagon-like peptide-1 (GLP-1) is a naturally occurring hormone involved in glucose-dependent signaling and gastrointestinal physiology
[8] Matyssek R, Le Thiec D, Lw M, Dizengremel P, Nunn AJ & Hberle KH (2006)
Such accumulation would sequester more amino acids, would increase transport out of the cell up to saturation, and would therefore increase the loss of cysteine to cystine in the blood