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In addition, IL-1, a cytokine known to enhance oxidative stress in the CNS, has been found to exert protective effects on both astrocytes and neurons by modulating GSH synthesis 88

10.3390/antiox11020318 8 BonanomiL.GazzanigaA

These results directly confirm that excessive NNMT activation suppresses NAD+ synthesis and impairs energy metabolism, while NNMT inhibition effectively reverses this process, establishing NNMT as a negative regulator of energy metabolism

The peptide corresponds to an active motif derived from thymosin beta-4 that is known to bind G-actin and regulate actin polymerization dynamics

Therapeutic and metagenomic potential of the biomolecular therapies against periodontitis and the oral microbiome: current evidence and future perspectives