Dysesthesia The TRIUMPH-4 trial data revealed a notable safety signal: dysesthesia (abnormal sensations like tingling, burning, or numbness) was reported in 8.8% of participants on the 9 mg dose and 20.9% on the 12 mg dose of retatrutide
According to the Zepbound label, the most frequent include nausea (24-29%), diarrhea (18-24%), vomiting (8-10%), and constipation (16-17%)
Real-time alerts ensure immediate visibility into emerging safety profiles, empowering sponsors and DSMBs to act without delay
These therapies are not FDA-approved for the treatment or prevention of disease
[DOI] [PMC free article] [PubMed] [Google Scholar] 42.Spasov A.A., Wikman G.K., Mandrikov V.B., Mironova I.A., Neumoin V.V