The normal course of untreated hyperuricemia, leading to progressive urate crystal deposition, begins with uric acid urolithiasis (urate kidney stones) and progresses to acute gouty arthritis, then intercritical gout and chronic tophaceous gout
In colorectal cancer (CRC) cells subjected to radiation-induced ER stress, PDI not only inhibits autophagy initiation by activating the GRP78-mTOR pathway but also competes with LC3 for binding to the mitochondrial autophagy receptor PHB2, thereby regulating the mitophagy process and reducing radiation sensitivity (44)
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If concomitant skin infections are present or develop, an appropriate antifungal or antibacterial agent should be used
Chen CY, Chan CH, Chen CM, Tsai YS, Tsai TY, Wu Lee YH, et al