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In a previous study, enhanced mTORC1 signaling was found to be dispensable for GC formation and serum antibody responses 102

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The metformin in tuberous sclerosis (MiTS) study: a randomised double-blind placebo-controlled trial

Namely, it is well established that GSTT1 enzyme is involved in bioactivation, rather than detoxification of several bifunctional alkylating agents, present in environmental pollution and certain occupational hazards 45

B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals