On-Label vs Off-Label and Compounded Products Vitamin B12 injections are an established medical treatment for confirmed B12 deficiency and related conditions (for example, pernicious anemia and certain malabsorption states), as summarized by the NIH Office of Dietary Supplements in its Vitamin B12 fact sheet for health professionals
J Trace Elem Med Biol 44:161176 Bhattacharya A, Seshadri M, Oven SD, Tth K, Vaughan MM, Rustum YM (2008) Tumor vascular maturation and improved drug delivery induced by methylselenocysteine leads to therapeutic synergy with anticancer drugs
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The daily injection requirement deters some patients but provides steady levels without the peaks and troughs of weekly dosing