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Correlates of immune and clinical activity of novel cancer vaccines
Several folate transporters have been identified and characterized: the reduced folate carrier, the folate receptors, and the proton-coupled folate transporter 881
We find that these interventions can partially prevent a loss of ovarian function and functional fertility caused by the anthracycline chemotherapy drug doxorubicin (Dox), and importantly, that this protection against infertility does not come at the cost of reduced efficacy of chemotherapy against cancer cell lines in vitro or tumour models in vivo
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