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A possible hypothesis is that aggregation is probably a consequence of oxidative modications of -synuclein [69]

This unique structure ensures stability in enzymes and offers a broad therapeutic scope

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on 24 patients with generalized vitiligo and 20 healthy controls found statistically significant higher levels of superoxide dismutase activity in erythrocytes, serum MDA, and nitric oxide (NO) and statistically significant lower levels of glutathione and glutathione peroxidase in the patients of vitiligo compared to the controls.[] Secondary to the oxidative stress, the polyunsaturated fatty acids undergo peroxidation resulting in formation of free radicals

Intermittent cycles of constipation and diarrhea, especially with mucus in the stool, should raise suspicion of leaky gut syndrome