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Moreover, it has been found that the dopaminergic fibers arising from the ventral tegmental area (VTA) project to the prefrontal cortex (PFC) and to regions of the limbic system, such as the nucleus accumbens (NAcc), forming the mesocorticolimbic (MCL) circuit

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Neuroinflammation, oxidative stress, excitotoxicity, growth factor deficiency, mitochondrial dysfunction, and synaptic loss all occur simultaneously

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Protein shakes designed for GLP-1 users and supplements for peptide therapy can help hit these targets even when appetite is severely suppressed