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221 Observational studies have found a higher incidence of birth defects in babies conceived via assisted reproductive techniques, especially those conceived using intracytoplasmic sperm injection

Nle-AngIV also increased spine numbers to 32 spines/50m, but to a lesser extent than Dihexa

PMID 21668043

Their mechanisms of actions include increasing excretion of urinary citrate, decreasing excretion of urinary calcium and oxalate, inhibition of the nucleation and growth of the calcium oxalate crystals, dissolving stones, raising the level of glycosaminoglycan, and being diuretic

It is correlated with Rasyan Chikitsa in Ayurveda