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This highlights the major influence of solubility and first-pass metabolism on systemic availability

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KL1 also synergized with rifampicin even when infected macrophages were pretreated with antibiotics, suggesting that low-energy persisters may be resuscitated and sensitized (Fig

A controlled human study found that combining the two produced six times more vomiting episodes than either drug alone, along with greater drops in blood pressure and oxygen levels

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