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A recent meta-analysis study reviewed twelve randomized controlled trials (RCTs) (n = 791) and found that ALC supplementation significantly reduced depressive symptoms in MDD as monotherapy and augmentation compared to placebo, with effect sizes comparable to standard antidepressants and a superior safety profile

Biochemistry and Molecular Biology Internals , 35(6), 1281-1297

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Similarly, peripheral inflammation originating in the gut and spreading through the bloodstream has been identified as a potential risk factor for AD, correlating with elevated amyloid levels in AD dementia [100, 101]