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Influences additional endocrine pathways: Compared to highly selective secretagogues, GHRP-6 may also influence ACTH and cortisol signaling in experimental models

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The GOT1-mediated glutamine metabolic pathway is a critical survival mechanism when the major glutamine pathway is inhibited, and it promotes tumorigenesis and development by replenishing the tricarboxylic acid (TCA) cycle, maintaining redox homeostasis, and providing the essential precursor, aspartic acid (Asp), for nucleotide production

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Among other metabolites that exhibited significant changes in the metabolomic analysis, spermidine (ratio: 1.3), a polyamine having strong anti-oxidant activity, acts as an intrinsic free radical scavenger