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2009 Oct-Nov;25(9-10):711-4

So if something goes wrong and the GSSG accumulates, it inhibits an enzyme that relies on the correct oxidation of the ER environment to operate a protein quality control system. Moreover, they discovered, when misfolded proteins dont pass quality control, they wont get exported, so they too pile up in the ER

Body weight of the test subjects was measured when the patients were screened, when they were randomly assigned to treatment groups, and at weeks 2, 4, 6, 8, 10, 14, 18, 22, 26, and 32 [1]

J Geront B Psychol Sci Soc Sci 2023;78(6):10731084