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However, in the pivotal Phase IIb trial, it failed to demonstrate statistically significant weight loss compared to placebo at the primary endpoint, leading the developer (Metabolic Pharmaceuticals Ltd.) to terminate the commercial program

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For procedures requiring gastric emptying or precise timing of oral medication administration, such as upper endoscopy or surgery requiring general anesthesia, the delayed gastric emptying effect of semaglutide may need to be considered

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This article examines the evidence, appropriate clinical indications, potential risks, and NHS guidance on B12 treatment and weight management