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Two of these case series suggest that dosage may be of importance, with individual differences and higher doses more effective than lower ones where dose was titrated up (dosage ranges 6001800 mg per day)

While roGFP2 WT was completely oxidized at even very low PfGrx C32S/C88S (SSG) concentrations, 1 M PfGrx C32S/C88S (SSG) glutathionylated approximately 50% of 1 M roGFP2 C151S (SH) suggesting that the redox couples roGFP2 C151S (SSG)/roGFP2 C151S (SH) and PfGrx C32S/C88S (SSG)/PfGrx C32S/C88S (SH) have very similar redox potentials

A number of synthetic endeavors have been instigated and are at various stages of development

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