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Toxic Dose: the therapeutic index (toxic/therapeutic dose ratio) for benzodiazepines is very high oral doses of diazepam that are 15-20 times the normal therapeutic dose have been reported without serious depression death from overdose with benzodiazepines alone is rare, however , respiratory arrest has been reported after rapid iv injection of benzodiazepines ingestion of other CNS-depressant drugs (ethanol, barbiturates, opioids) will produce additive effects (Olson 2007)