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10.1098/rstb.2010.0230 68 RosensteinE

The intracellular domain has three portions: a juxtamembrane sequence that downregulates kinase activity which is followed by phosphorylation of Ser975 which is a catalytic region that promotes kinase activity leading to transphosphorylation of Tyr1234 and Tyr1235

Pharmacological management of obesity: an endocrine Society clinical practice guideline

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