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113 Besides, because of the high plasticity of the metabolic network and metabolite exchange among cancer and stromal cells, a compensatory response can be readily induced to produce limiting metabolites

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Compartmentalization of cyclic AMP phosphodiesterases, signalling 'crosstalk', desensitization and the phosphorylation of Gi-2 add cell specific personalization to the control of the levels of the second messenger cyclic AMP

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